Roadmap of DNA methylation in breast cancer identifies novel prognostic biomarkers

  title={Roadmap of DNA methylation in breast cancer identifies novel prognostic biomarkers},
  author={Bernardo P. de Almeida and Joana Dias Apol{\'o}nio and Alexander R. Binnie and Pedro Castelo-Branco},
  journal={BMC Cancer},
BackgroundBreast cancer is a highly heterogeneous disease resulting in diverse clinical behaviours and therapeutic responses. DNA methylation is a major epigenetic alteration that is commonly perturbed in cancers. The aim of this study is to characterize the relationship between DNA methylation and aberrant gene expression in breast cancer.MethodsWe analysed DNA methylation and gene expression profiles from breast cancer tissue and matched normal tissue in The Cancer Genome Atlas (TCGA). Genome… 

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