Road Map for the Structure-Based Design of Selective Covalent HCV NS3/4A Protease Inhibitors.

Abstract

Over the last 2 decades, covalent inhibitors have gained much popularity and is living up to its reputation as a powerful tool in drug discovery. Covalent inhibitors possess many significant advantages including increased biochemical efficiency, prolonged duration and the ability to target shallow, solvent exposed substrate-binding domains. However, rapidly… (More)
DOI: 10.1007/s10930-017-9736-8

Topics

Cite this paper

@article{Shunmugam2017RoadMF, title={Road Map for the Structure-Based Design of Selective Covalent HCV NS3/4A Protease Inhibitors.}, author={Letitia Shunmugam and Pritika Ramharack and Mahmoud Sanad Soliman}, journal={The protein journal}, year={2017}, volume={36 5}, pages={397-406} }