Rnf19a, a ubiquitin protein ligase, and Psmc3, a component of the 26S proteasome, tether to the acrosome membranes and the head-tail coupling apparatus during rat spermatid development.

@article{Rivkin2009Rnf19aAU,
  title={Rnf19a, a ubiquitin protein ligase, and Psmc3, a component of the 26S proteasome, tether to the acrosome membranes and the head-tail coupling apparatus during rat spermatid development.},
  author={Eugene Rivkin and Abraham L. Kierszenbaum and Mara Gil and Laura L. Tres},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2009},
  volume={238 7},
  pages={1851-61}
}
We report the cDNA cloning of rat testis Rnf19a, a ubiquitin protein ligase, and show 98% and 93% protein sequence identity of testicular mouse and human Rnf19a, respectively. Rnf19a interacts with Psmc3, a protein component of the 19S regulatory cap of the 26S proteasome. During spermatid development, Rnf19a and Psmc3 are initially found in Golgi-derived proacrosomal vesicles. Later on, Rnf19a, Psmc3, and ubiquitin are seen along the cytosolic side of the acrosomal membranes and the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 35 references

A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity.

Biochemical and biophysical research communications • 2001
View 3 Excerpts
Highly Influenced

Expres - sion of full - length and truncated Fyn tyrosine kinase transcripts and encoded proteins during spermatogenesis and localization during acrosome biogenesis and fertilization

AL Kierszenbaum, E Rivkin, R Shalgi, LL Tres
2009

The acroplaxome is the docking site of Golgiderived myosin Va / Rab 27 a / bcontaining proacrosomal vesicles in wild - type and Hrb mutant mouse spermatids

AL Kierszenbaum, LL Tres, E Rivkin, N Kang-Decker, JM vanDeursen
Biol . Reprod • 2004

Similar Papers

Loading similar papers…