Rme1, a negative regulator of meiosis, is also a positive activator of G1 cyclin gene expression.

@article{Toone1995Rme1AN,
  title={Rme1, a negative regulator of meiosis, is also a positive activator of G1 cyclin gene expression.},
  author={William Toone and A. L. Johnson and Geoffrey R. Banks and J. H. Toyn and David Stuart and Curt Wittenberg and L. H. Johnston},
  journal={The EMBO journal},
  year={1995},
  volume={14 23},
  pages={5824-32}
}
Control of G1 cyclin expression in Saccharomyces cerevisiae is mediated primarily by the transcription factor SBF (Swi4/Swi6). In the absence of Swi4 and Swi6 cell viability is lost, but can be regained by ectopic expression of the G1 cyclin encoding genes, CLN1 or CLN2. Here we demonstrate that the RME1 (regulator of meiosis) gene can also bypass the normally essential requirement for SBF. RME1 encodes a zinc finger protein which is able to repress transcription of IME1 (inducer of meiosis… CONTINUE READING