Rme-1 regulates the recycling of the cystic fibrosis transmembrane conductance regulator.

@article{Picciano2003Rme1RT,
  title={Rme-1 regulates the recycling of the cystic fibrosis transmembrane conductance regulator.},
  author={John A Picciano and Nadia Farouk El Ameen and Barth D Grant and Neil A. Bradbury},
  journal={American journal of physiology. Cell physiology},
  year={2003},
  volume={285 5},
  pages={C1009-18}
}
Endocytic motifs in the carboxyl terminus of cystic fibrosis transmembrane conductance regulator (CFTR) direct internalization from the plasma membrane by clathrin-mediated endocytosis. However, the fate of such internalized CFTR has remained unknown. Internalized membrane proteins can be either targeted for degradation or recycled back to the plasma membrane. Using cell surface biotinylation and antibody uptake studies, we show that CFTR undergoes constitutive endocytosis and recycling back to… CONTINUE READING