Rizatriptan has central antinociceptive effects against durally evoked responses.

@article{Cumberbatch1997RizatriptanHC,
  title={Rizatriptan has central antinociceptive effects against durally evoked responses.},
  author={Michael J Cumberbatch and R. R. Hill and Richard J. Hargreaves},
  journal={European journal of pharmacology},
  year={1997},
  volume={328 1},
  pages={37-40}
}
The 5-HT(1B/1D) receptor agonist rizatriptan constricts intracranial, extracerebral blood vessels, inhibits neurogenic vasodilation and extravasation in the meninges and is effective clinically against migraine. The present study has investigated whether rizatriptan may also have activity at 5-HT(1B/1D) receptors within the central nervous system (CNS) that contributes to its antimigraine effects. Action potentials evoked by electrical stimulation of the dura-mater were recorded extracellularly… CONTINUE READING

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