Rivaroxaban transfer across the dually perfused isolated human placental cotyledon.


OBJECTIVE The purpose of this study was to determine the rate and extent of rivaroxaban transfer across the term human placenta and determine whether passive diffusion was the primary mechanism involved in this transfer. STUDY DESIGN The transplacental pharmacokinetics of rivaroxaban was determined with the ex-vivo placenta perfusion model. Rivaroxaban… (More)
DOI: 10.1016/j.ajog.2015.06.065


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