Rituximab versus azathioprine for maintenance in ANCA-associated vasculitis.

  title={Rituximab versus azathioprine for maintenance in ANCA-associated vasculitis.},
  author={L{\"o}ic Guillevin and Christian Pagnoux and Alexandre Karras and Chah{\'e}ra Khouatra and Olivier Auma{\^i}tre and Pascal Cohen and François Maurier and Olivier Decaux and Jacques Ninet and Pierre Gobert and Thomas Qu{\'e}m{\'e}neur and Claire Blanchard-Delaunay and Pascal Godmer and Xavier Pu{\'e}chal and P L Carron and Pierre-yves Hatron and Nicolas Limal and Mohamed Amine Hamidou and Maize Ducret and {\'E}ric Daugas and Thomas Papo and Bernard Bonnotte and Alfred Mahr and Philippe Ravaud and Luc Mouthon},
  journal={The New England journal of medicine},
  volume={371 19},
BACKGROUND The combination of cyclophosphamide and glucocorticoids leads to remission in most patients with antineutrophil cytoplasm antibody (ANCA)-associated vasculitides. However, even when patients receive maintenance treatment with azathioprine or methotrexate, the relapse rate remains high. Rituximab may help to maintain remission. METHODS Patients with newly diagnosed or relapsing granulomatosis with polyangiitis, microscopic polyangiitis, or renal-limited ANCA-associated vasculitis in… CONTINUE READING


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Granulomato - sis with polyangiitis ( Wegener ’ s ) : impact of maintenance therapy duration

  • GS Hoffman
  • Medi - cine ( Baltimore )
  • 2014

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