Rituximab versus Mycophenolate Mofetil in Patients with Pemphigus Vulgaris.

  title={Rituximab versus Mycophenolate Mofetil in Patients with Pemphigus Vulgaris.},
  author={Victoria P. Werth and Pascal Joly and Daniel Mimouni and Emanual Maverakis and Fr{\'e}d{\'e}ric Caux and Patricia B. Lehane and L. Gearhart and Audrey Kapre and Pooneh Pordeli and Diana M. Chen},
  journal={The New England journal of medicine},
BACKGROUND Rituximab and mycophenolate mofetil are used to treat pemphigus vulgaris, but they have not been adequately compared in clinical trials. METHODS In a randomized, controlled trial, we assigned patients with moderate-to-severe pemphigus vulgaris in a 1:1 ratio to receive intravenous rituximab (1000 mg on days 1, 15, 168, and 182) or oral mycophenolate mofetil (2 g per day), in addition to an oral glucocorticoid administered on the same tapering schedule in the two groups. The primary… 

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