Rituximab specifically depletes short-lived autoreactive plasma cells in a mouse model of inflammatory arthritis.

@article{Huang2010RituximabSD,
  title={Rituximab specifically depletes short-lived autoreactive plasma cells in a mouse model of inflammatory arthritis.},
  author={Haochu Huang and C. Benoist and Diane Mathis},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 10},
  pages={4658-63}
}
There is increasing appreciation of the important role of B cells in many autoimmune diseases and consequently, increasing interest in treating these disorders through B cell-depletion therapy with rituximab, an anti-CD20 monoclonal antibody. Yet, precisely how this and related drugs exert their therapeutic effects remains controversial. In particular, it is unclear how, in a number of contexts, rituximab can greatly reduce the titer of serum autoantibodies without substantially altering the… CONTINUE READING

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