Rituximab plus bendamustine is active in pretreated patients with extragastric marginal zone B cell lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma)

@article{Kiesewetter2014RituximabPB,
  title={Rituximab plus bendamustine is active in pretreated patients with extragastric marginal zone B cell lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma)},
  author={Barbara Kiesewetter and Marius E. Mayerhoefer and Julius R Lukas and Christoph Carl Zielinski and Leonhard M{\"u}llauer and Markus Raderer},
  journal={Annals of Hematology},
  year={2014},
  volume={93},
  pages={249-253}
}
Recently, the combination of rituximab and bendamustine (R-Benda) has been defined as highly active in patients with follicular lymphomas, but little is known about the efficacy of R-Benda in mucosa-associated lymphoid tissue (MALT) lymphoma. In a retrospective analysis, we have defined 14 patients with MALT lymphoma undergoing therapy with R-Benda. Seven patients were female and seven male (aged 44–88 years), and all had relapsed extragastric MALT lymphoma. R-Benda was given at first relapse… 

A single center experience: rituximab plus cladribine is an effective and safe first-line therapy for unresectable bronchial-associated lymphoid tissue lymphoma.

Although further large-scale study is needed for consolidation, R-2-CdA regimen could be a good first-line therapy option for patients with unresectable BALT lymphoma.

Efficacy and safety of rituximab plus bendamustine for gastric marginal zone lymphoma

This single-center retrospective study based on a cohort of 13 consecutive and homogeneously treated gastric MALT lymphoma patients diagnosed at the authors' Institution between 2013 and 2017 investigated efficacy and safety of BR as first-line treatment for patients with multifocal, HP negative or persistent disease evaluated by gastroscopy after HP eradication.

Frontline treatment with chemoimmunotherapy for limited-stage ocular adnexal MALT lymphoma with adverse factors: a phase II study

This phase II study demonstrated durable efficacy of R-CVP chemoimmunotherapy, which has promise as an alternative frontline therapy for the limited-stage OAML patients with adverse prognostic factors.

Current therapeutic concepts in mucosa-associated lymphoid tissue (MALT) lymphoma

This short review focuses on highlights and recent results of systemic and antimicrobial therapy in MALT lymphoma.

Bendamustine hydrochloride in patients with B-cell malignancies who have comorbidities – is there an optimal dose?

Even with the introduction of targeted therapies, bendamustine will likely continue to be an important therapeutic option in patients with comorbidities because of its tolerability, efficacy and cost.

A phase II study of oxaliplatin and prednisone for patients with relapsed or refractory marginal zone lymphoma: Consortium for Improving Survival of Lymphoma trial

Salvage Ox-P chemotherapy for patients with relapsed or refractory MZL at the stated dosage and schedule showed moderate clinical activity and was considerable in very few selected patients (NCT01068392).

Targeting Bruton tyrosine kinase with ibrutinib in relapsed/refractory marginal zone lymphoma.

Single-agent ibrutinib induced durable responses with a favorable benefit-risk profile in patients with previously treated MZL, confirming the role of BCR signaling in this malignancy.

Chemoimmunotherapy for Mucosa-Associated Lymphoid Tissue-Type Lymphoma: A Review of the Literature.

Patients with MALT lymphoma should be treated within prospective trials to further define optimal therapeutic strategies, and systemic treatment is a reasonable option with potentially curative intent in everyday practice.

Long‐term safety and activity of cladribine in patients with extranodal B‐cell marginal zone lymphoma of the mucosa‐associated lymphoid tissue (MALT) lymphoma

The data suggest that cladribine might be safely applied in patients with MALT lymphoma, also in terms of long‐term toxicities and confirm the potential ofcladribine to induce durable remissions.

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Moderate-dose RT achieved excellent local control in localized MALT lymphomas and had curative potential for three fourths of the patients, and Gastric and thyroid MALT glands had better outcome, whereas distant failures were common for other sites.