Rituximab induces clinical stabilization in a patient with fulminant multiple sclerosis not responding to natalizumab

  title={Rituximab induces clinical stabilization in a patient with fulminant multiple sclerosis not responding to natalizumab},
  author={Verena Isabell Leussink and Helmar Christoph Lehmann and Gerd Meyer zu H{\"o}rste and H. P. Hartung and Olaf St{\"u}ve and Bernd C. Kieseier},
  journal={Journal of Neurology},
JO N 2 95 6 II trial in relapsing-remitting MS (RRMS) [6–9]. At present, the duration of the treatment effect, its effect on progression of disability, and types of adverse events associated with this drug that may occur remain elusive [10]. We report an 18-year old righthanded Caucasian male who was diagnosed with RRMS in 2001 at the age of 12 years by a neurologist in private practice. At that time, the patient experienced 3–4 relapses per year, and treatment was initiated with interferon… 

Management of Fulminant Multiple Sclerosis With Rituximab: A Case Report

Rituximab treatment should be considered for a patient with fulminant MS who responded well to plasmapheresis who was previously well controlled with natalizumab and continued to have worsening disease activity despite fingolimod treatment.

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Autoimmune disease: A role for new anti-viral therapies?

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A single course of rituximab reduced inflammatory brain lesions and clinical relapses for 48 weeks and provides evidence of B-cell involvement in the pathophysiology of relapsing-remitting multiple sclerosis.

A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis.

Natalizumab reduced the risk of the sustained progression of disability and the rate of clinical relapse in patients with relapsing multiple sclerosis and hold promise as an effective treatment for relapsed multiple sclerosis.

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Natalizumab added to interferon beta-1a was significantly more effective in patients with relapsing multiple sclerosis, and additional research is needed to elucidate the benefits and risks of this combination treatment.

Clinical stabilization and effective B-lymphocyte depletion in the cerebrospinal fluid and peripheral blood of a patient with fulminant relapsing-remitting multiple sclerosis.

Beneficial clinical effects of rituximab in relapsing-remitting MS, mediated through modulation of humoral systemic and central nervous system intrinsic immune responses, are demonstrated.

Treatment and treatment trials in multiple sclerosis

Enhanced understanding of the immunopathological processes that underlie the disease, advances in biotechnology and development of powerful magnetic resonance imaging technologies, together with improvements in clinical trial design have led to a variety of valuable therapeutic approaches, which are currently being studied in detail.

Altered CD4+/CD8+ T-cell ratios in cerebrospinal fluid of natalizumab-treated patients with multiple sclerosis.

Natalizumab therapy decreased the CSF CD4(+)/CD8(+) ratio of patients with MS to levels similar to those of human immunodeficiency virus-infected patients, which may have implications for the observation that some natalizUMab-treated Patients with MS developed progressive multifocal leukoencephalopathy.

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Recent findings obtained with both animal models and patients with multiple sclerosis indicate involvement of a T helper cell with a TH-17 phenotype, in contrast to previous data indicating that T helper type 1 cells are critical.

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Recent evidence is described that the spectrum of MS pathology is much broader, including demyelination in the cortex and deep gray matter nuclei, as well as diffuse injury of the normal‐appearing white matter.