Rituximab in the treatment of refractory or relapsing eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)

@article{Thiel2013RituximabIT,
  title={Rituximab in the treatment of refractory or relapsing eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)},
  author={Jens Thiel and Fabian H{\"a}ssler and Ulrich Salzer and Reinhard Edmund Voll and Nils Venhoff},
  journal={Arthritis Research \& Therapy},
  year={2013},
  volume={15},
  pages={R133 - R133}
}
IntroductionEosinophilic granulomatosis with polyangiitis (EGPA) is part of antineutrophil cytoplasmic antibodies (ANCAs)-associated vasculitides. In EGPA small-vessel vasculitis is associated with eosinophilia and asthma. About 40% of EGPA patients are ANCA-positive, suggesting a role for B cells in the pathogenesis of EGPA. B cell-depleting therapy with rituximab (RTX) can be effective in ANCA-positive EGPA, but very few patients have been published to date. The role of RTX in the treatment… 

Rituximab for the treatment of eosinophilic granulomatosis with polyangiitis (Churg–Strauss)

TLDR
The treatment of EGPA with rituximab resulted in high rates of improvement and reduced requirement of prednisolone, and may be considered for the treatment ofEGPA.

Optimal therapy and prospects for new medicines in eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)

TLDR
Treatment for EGPA still has several unmet needs, and several biologic agents are now under investigation in randomized controlled trials, but a few others should be considered soon.

Biological drugs in ANCA-associated vasculitis.

Omalizumab in patients with eosinophilic granulomatosis with polyangiitis: a 36-month follow-up study

TLDR
In patients with EGPA and moderate to severe allergic asthma, omalizumab can be beneficial and safe and enables corticosteroid tapering while decreasing eosinophilia and improving asthma symptoms over 36 months.

Eosinophilic Granulomatosis with Polyangiitis (EGPA, Churg–Strauss)

TLDR
Recent advances in EGPA management, including several novel immunomodulatory drugs and biotherapies, were or are being evaluated to improve EGPA patients’ prognoses.

Pharmacological approach to treating eosinophilic granulomatosis with polyangiitis (Churg–Strauss)

TLDR
The standard of care for EGPA; the different therapeutic options available; and forthcoming therapeutic perspectives are reviewed, based on pathogenesis and clinical characteristics.

Successful use of Rituximab in a patient with recalcitrant multisystemic eosinophilic granulomatosis with polyangiitis

TLDR
A case of a 56-year-old woman with a long-standing history of asthma, who presented with an acute sudden painless loss of vision after she had been recently diagnosed with EGPA and induced with pulse steroids and cyclophosphamide, and responded remarkably to Rituximab.
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