Rituximab in relapsed or refractory hairy cell leukemia.

  title={Rituximab in relapsed or refractory hairy cell leukemia.},
  author={Deborah A. Thomas and Susan M O'Brien and Carlos E Bueso-Ramos and Stefan H Faderl and Michael J Keating and Francis J Giles and Jorge E. Cortes and Hagop M Kantarjian},
  volume={102 12},
The purpose of this study was to investigate the efficacy and safety of the monoclonal antibody, rituximab, in relapsed or refractory hairy cell leukemia (HCL). Fifteen patients with relapsed or primary refractory HCL after nucleoside analogs received rituximab 375 mg/m2 weekly for a total of 8 planned doses. An additional 4 doses could be administered to responders who had not achieved complete response (CR). The overall response rate was 80%. Eight patients (53%) achieved CR, 2 (13%) attained… CONTINUE READING


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