Rituximab in a patient with multiple sclerosis--effect on B cells, plasma cells and intrathecal IgG synthesis.

@article{Petereit2007RituximabIA,
  title={Rituximab in a patient with multiple sclerosis--effect on B cells, plasma cells and intrathecal IgG synthesis.},
  author={H. F. Petereit and Walter Moeller-Hartmann and Dirk Reske and Andrea Rubbert},
  journal={Acta neurologica Scandinavica},
  year={2007},
  volume={117 6},
  pages={
          399-403
        }
}
OBJECTIVE To study the time course of immunoglobulin, B and plasma cells in the blood and cerebrospinal fluid (CSF) before and during rituximab treatment in a patient with severe relapsing-remitting multiple sclerosis (MS) in relation to clinical and MRI findings. METHODS Immunoglobulins in the CSF were measured by nephelometry and detected by isoelectrical focussing. CSF and blood cell subtypes from seven time points were analysed by flow cytometry. RESULTS Treatment with rituximab induced… CONTINUE READING
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