Rituximab for the treatment of rheumatoid arthritis.

  title={Rituximab for the treatment of rheumatoid arthritis.},
  author={Arthur A. Schuna},
  volume={27 12},
Rituximab has been approved by the United States Food and Drug Administration in combination with methotrexate for the treatment of rheumatoid arthritis in patients who failed to achieve adequate benefit from tumor necrosis factor-alpha inhibitors. Rituximab is a biologic agent that depletes peripheral B cells--an action thought to reduce rheumatoid arthritis activity--and induces prolonged clinical improvement. Two 1000-mg infusions administered 2 weeks apart can result in a response that… CONTINUE READING

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