Rituximab exerts a dual effect in pemphigus vulgaris.

  title={Rituximab exerts a dual effect in pemphigus vulgaris.},
  author={Ruediger Eming and Angela Nagel and Sonja Wolff-Franke and Eva Podstawa and Dirk Debus and Michael Hertl},
  journal={The Journal of investigative dermatology},
  volume={128 12},
Pemphigus vulgaris (PV) is a severe autoimmune blistering disease affecting the skin and mucous membranes. Autoreactive CD4(+) T helper (Th) lymphocytes are crucial for the autoantibody response against the desmosomal adhesion molecules, desmoglein (dsg)-3 and dsg1. Eleven patients with extensive PV were treated with the anti-CD20 antibody, rituximab (375 mg per m(2) body surface area once weekly for 4 weeks). Frequencies of autoreactive CD4(+) Th cells in the peripheral blood of the PV… CONTINUE READING