Rituximab-dependent cytotoxicity by natural killer cells: influence of FCGR3A polymorphism on the concentration-effect relationship.

@article{DallOzzo2004RituximabdependentCB,
  title={Rituximab-dependent cytotoxicity by natural killer cells: influence of FCGR3A polymorphism on the concentration-effect relationship.},
  author={S{\'e}bastien Dall'Ozzo and Sophie Tartas and Gilles Paintaud and Guillaume Cartron and Philippe Colombat and Pierre Bardos and Herv{\'e} Watier and Gilles Thibault},
  journal={Cancer research},
  year={2004},
  volume={64 13},
  pages={4664-9}
}
The FCGR3A gene dimorphism generates two allotypes: FcgammaRIIIa-158V and FcgammaRIIIa-158F. The genotype homozygous for FcgammaRIIIa-158V (VV) is associated with higher clinical response to rituximab, a chimeric anti-CD20 IgG1 used in the treatment of B lymphoproliferative malignancies. Our objective was to determine whether this genetic association relates to rituximab-dependent cytotoxicity mediated by FcgammaRIIIa/CD16a+ cells. The number of CD16+ circulating monocytes, T cells, and natural… CONTINUE READING
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