Ritonavir: An Extraordinary Example of Conformational Polymorphism

  title={Ritonavir: An Extraordinary Example of Conformational Polymorphism},
  author={John Bauer and S. Spanton and R. Henry and J. Quick and W. Dziki and W. Porter and J. Morris},
  journal={Pharmaceutical Research},
  • John Bauer, S. Spanton, +4 authors J. Morris
  • Published 2004
  • Medicine, Chemistry
  • Pharmaceutical Research
  • AbstractPurpose. In the summer of 1998, Norvir semi-solid capsules supplies were threatened as a result of a new much less soluble crystal form of ritonavir. This report provides characterization of the two polymorphs and the structures and hydrogen bonding network for each form. Methods. Ritonavir polymorphism was investigated using solid state spectroscopy and microscopy techniques including solid state NMR, Near Infrared Spectroscopy, powder X-ray Diffraction and Single crystal X-ray. A… CONTINUE READING
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