Ritanserin facilitates anxiety in a simulated public-speaking paradigm.

  title={Ritanserin facilitates anxiety in a simulated public-speaking paradigm.},
  author={Francisco S Guimar{\~a}es and Patrick Mbaya and J F William Deakin},
  journal={Journal of psychopharmacology},
  volume={11 3},
The effects of ritanserin, a 5-HT2A/2C (5-hydroxytryptamine) antagonist, have been investigated in simulated public speaking with healthy volunteers. The aim was to investigate the role of 5-HT in subjective experimental anxiety. There were three experimental groups each comprising four or five males and 11 females. Subjects received placebo, ritanserin 2.5 or 10 mg, p.o. They rated themselves using the Spielberger State-Trait Anxiety Inventory and visual analogue scales factored into anxiety… CONTINUE READING