Ritanserin attenuates anorectic, endocrine and thermic responses tod-fenfluramine in human volunteers

Abstract

This study investigated the role of the 5-HT2/1C receptor antagonist ritanserin ond-fenfluramine (d-FF) induced changes in food intake, prolactin (PRL) secretion and oral temperature in 12 healthy male volunteers. The study was double blind and placebo controlled. Food intake was measured using an automated food dispenser.d-FF (30 mg) significantly reduced fat intake. While ritanserin (5 mg) had no effect when given alone it abolished thed-FF induced reduction in fat intake. In addition, ritanserin abolished thed-FF induced rise in PRL and oral temperature. The results suggest that 5-HT2 or 5-HT1C receptors mediate the effects ofd-fenfluramine on appetite, prolactin secretion and temperature in humans.

DOI: 10.1007/BF02244895

6 Figures and Tables

Statistics

05001000'95'97'99'01'03'05'07'09'11'13'15'17
Citations per Year

5,663 Citations

Semantic Scholar estimates that this publication has 5,663 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Goodall1993RitanserinAA, title={Ritanserin attenuates anorectic, endocrine and thermic responses tod-fenfluramine in human volunteers}, author={Ellen Goodall and Philip J. Cowen and Mervyn Franklin and Trevor Silverstone}, journal={Psychopharmacology}, year={1993}, volume={112}, pages={461-466} }