Rit, a non-lipid-modified Ras-related protein, transforms NIH3T3 cells without activating the ERK, JNK, p38 MAPK or PI3K/Akt pathways

@article{Rusyn2000RitAN,
  title={Rit, a non-lipid-modified Ras-related protein, transforms NIH3T3 cells without activating the ERK, JNK, p38 MAPK or PI3K/Akt pathways},
  author={Elena V. Rusyn and Evangeline R Reynolds and Haipeng Shao and Theresa M. Grana and Tung O. Chan and Douglas A. Andres and Adrienne D. Cox},
  journal={Oncogene},
  year={2000},
  volume={19},
  pages={4685-4694}
}
The biological functions of Rit (Ras-like protein in tissues) and Rin (Ras-like protein in neurons), members of a novel branch of Ras-related GTP-binding proteins that are ∼50% identical to Ras, have not been characterized. Therefore, we assessed their activity in growth control, transformation and signaling. NIH cells stably expressing a constitutively activated mutant of Rit [Rit(79L)] (analogous to the oncogenic mutant H-Ras(61L)) demonstrated strong growth transformation, proliferating… CONTINUE READING
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