Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding

@article{Schotte1996RisperidoneCW,
  title={Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding},
  author={Alain Schotte and Paul M. F. Janssen and Walter Gommeren and Walter H.M.L. Luyten and Paul T. Van Gompel and Anne Simone Josephine Lesage and K. De Loore and Jos{\'e}e E. Leysen},
  journal={Psychopharmacology},
  year={1996},
  volume={124},
  pages={57-73}
}
Risperidone and its active metabolite 9-OH-risperidone were compared to reference antipsychotic drugs (haloperidol, pipamperone, fluspirilene, clozapine, zotepine) and compounds under development (olanzapine, seroquel, sertindole, ORG-5222, ziprasidone) for in vitro binding to neurotransmitter receptors in brain tissue and on membranes of recombinant cells expressing cloned human receptors and for in vivo occupancy of neurotransmitter receptors in rat and guinea-pig brain following acute… CONTINUE READING
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