Risperidone ameliorates post-traumatic stress disorder-like symptoms in modified stress re-stress model

@article{Krishnamurthy2013RisperidoneAP,
  title={Risperidone ameliorates post-traumatic stress disorder-like symptoms in modified stress re-stress model},
  author={Sairam Krishnamurthy and Debapriya Garabadu and Keerikkattil Paily Joy},
  journal={Neuropharmacology},
  year={2013},
  volume={75},
  pages={62-77}
}
The management for post-traumatic stress disorder (PTSD) involves chronic administration of drugs. We have modified the stress re-stress (SRS) model to study the effect of chronic administration of risperidone (RIS) after induction of PTSD in rats. On day-1 (D-1) rats underwent training session for elevated-plus maze (EPM) test. On D-2, rats were subjected to stress protocol of 2 h restraint and 20 min forced-swim test (FST) followed by halothane anesthesia. The rats were exposed to re-stress… CONTINUE READING
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