Risperidone Dose-Dependently Increases Extracellular Concentrations of Serotonin in the Rat Frontal Cortex: Role of α2 –Adrenoceptor Antagonism

@article{Hertel1997RisperidoneDI,
  title={Risperidone Dose-Dependently Increases Extracellular Concentrations of Serotonin in the Rat Frontal Cortex: Role of α2 –Adrenoceptor Antagonism},
  author={Peter Hertel and George G. Nomikos and Bj{\"o}rn Schilstr{\"o}m and Lotta Arborelius and Torgny H. Svensson},
  journal={Neuropsychopharmacology},
  year={1997},
  volume={17},
  pages={44-55}
}
We have previously shown that risperidone, an antipsychotic drug with high affinity for 5-hydroxytryptamine (5-HT)2A and dopamine (DA)2 receptors, as well as for α1- and α2-adrenoceptors, enhances 5-HT metabolism selectively in the rat frontal cortex (FC). To further study the influence of risperidone on central 5-HT systems, we compared its effects on dialysate 5-HT in the FC, as assessed by microdialysis, with those obtained with other antipsychotic drugs, i.e., clozapine, haloperidol, and… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 31 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 65 references

The Rat Brain in Stereotaxic Coordinates

Trends in Neurosciences • 1984
View 4 Excerpts
Highly Influenced

The risks and benefits of clozapine versus chlorpromazine.

Journal of clinical psychopharmacology • 1987
View 6 Excerpts
Highly Influenced

Choice of neuroleptics based on in vitro pharmacology

PS Van Wielinck, JE Leysen
J Drug Res • 1983
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…