Risks of untreated and treated isolated systolic hypertension in the elderly: meta-analysis of outcome trials
@article{Staessen2000RisksOU, title={Risks of untreated and treated isolated systolic hypertension in the elderly: meta-analysis of outcome trials}, author={Jan A. Staessen and Jerzy Gąsowski and Ji G. Wang and Lutgarde Thijs and Elly Den Hond and Jean-Pierre Boissel and J. A. R. Coope and Tork Ekbom and François Gueyffier and Li-sheng Liu and Karla Kerlikowske and Stuart Pocock and Robert H. Fagard}, journal={The Lancet}, year={2000}, volume={355}, pages={865-872} }
1,157 Citations
The benefit of treating isolated systolic hypertension
- MedicineCurrent hypertension reports
- 2001
The pooled results of 15,693 older patients with isolated systolic hypertension prove that antihypertensive drug treatment is justified if systolics blood pressure on repeated clinic measurements is 160 mm Hg or higher.
Improved Outcomes with Antihypertensive Medication in the Elderly with Isolated Systolic Hypertension
- MedicineDrugs & aging
- 2001
The pooled results of 15 693 older patients with isolated systolic hypertension prove that antihypertensive drug treatment is justified if on repeated clinic measurements SBP is 160mm Hg or higher.
Benefits of antihypertensive drug treatment in elderly patients with isolated systolic hypertension.
- MedicineThe Netherlands journal of medicine
- 2001
Treatment strategies for isolated systolic hypertension in elderly patients
- MedicineExpert opinion on pharmacotherapy
- 2020
The authors systematically review published studies to appraise the scientific and clinical evidence supporting the role of blood pressure control in elderly patients with isolated systolic hypertension, and to assess the influence of different drug treatment regimens on outcomes.
Extent of cardiovascular risk reduction associated with treatment of isolated systolic hypertension.
- MedicineArchives of internal medicine
- 2003
Treatment of ISH in older adults results in reduced event rates in 14 years, and treatment before advanced atherosclerosis develops will likely produce the best long-term outcome.
Risk and benefit of treatment of isolated systolic hypertension in the elderly: evidence from the Systolic Hypertension in Europe Trial
- MedicineCurrent opinion in cardiology
- 2001
A meta-analysis partly based on Syst-Eur data showed that in older hypertensive patients pulse pressure and not mean pressure is the major determinant of cardiovascular risk.
Target Blood Pressure for Treatment of Isolated Systolic Hypertension in the Elderly: Valsartan in Elderly Isolated Systolic Hypertension Study
- MedicineHypertension
- 2010
Blood pressure targets of <140 mm Hg are safely achievable in relatively healthy patients ≥70 years of age with isolated systolic hypertension, although this trial was underpowered to definitively determine whether strict control was superior to less stringent blood pressure targets.
Pulsatile blood pressure component as predictor of mortality in hypertension: a meta-analysis of clinical trial control groups
- MedicineJournal of hypertension
- 2002
In hypertensive patients pulse pressure, not mean pressure, is associated with an increased risk of fatal events, and this appears to be true in a broad range of patients with hypertension.
Perspectives on treatment of hypertension in elderly patients
- MedicineWiener Medizinische Wochenschrift
- 2004
It is not appropriate to limit the choice of initial drugs for hypertensive older individuals to a single class of agents, since so many older people have other medical problems that affect this decision and reaching the target blood pressure is the determinant factor for cardiovascular risk reduction.
Principal Results of the Japanese Trial to Assess Optimal Systolic Blood Pressure in Elderly Hypertensive Patients (JATOS)
- MedicineHypertension Research
- 2008
The benefits of lowering a systolic blood pressure below 140 mmHg in elderly hypertension remain controversial. This study is a prospective, randomized, open-label study with blinded assessment of…
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