Risks associated with statin therapy: a systematic overview of randomized clinical trials.

@article{Kashani2006RisksAW,
  title={Risks associated with statin therapy: a systematic overview of randomized clinical trials.},
  author={A. Kashani and Christopher O. Phillips and Joanne Micale Foody and Yongfei Wang and Sandeep S Mangalmurti and Dennis T. Ko and Harlan M. Krumholz},
  journal={Circulation},
  year={2006},
  volume={114 25},
  pages={2788-97}
}
BACKGROUND Although statins reduce the risk of cardiovascular events, concerns about adverse effects may deter physicians from prescribing these agents. We performed a systematic overview of randomized statin trials to quantify the risks of musculoskeletal, renal, and hepatic complications associated with therapy. METHODS AND RESULTS Major statin trials were identified by electronic search of the MEDLINE database from 1966 to December 2005. We included English language reports of adults with… CONTINUE READING

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