Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial

@article{Rossouw2002RisksAB,
  title={Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial},
  author={J. Rossouw and G. Anderson and R. Prentice and A. LaCroix and C. Kooperberg and M. Stefanick and R. Jackson and S. Beresford and B. Howard and Karen C Johnson and J. Kotchen and J. Ockene},
  journal={Obstetrics \& Gynecology},
  year={2002},
  volume={101},
  pages={194}
}
CONTEXT Despite decades of accumulated observational evidence, the balance of risks and benefits for hormone use in healthy postmenopausal women remains uncertain. OBJECTIVE To assess the major health benefits and risks of the most commonly used combined hormone preparation in the United States. DESIGN Estrogen plus progestin component of the Women's Health Initiative, a randomized controlled primary prevention trial (planned duration, 8.5 years) in which 16608 postmenopausal women aged 50… Expand

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Treatment with oral conjugated equine estrogen plus medroxyprogesterone acetate did not reduce the overall rate of CHD events in postmenopausal women with established coronary disease, and the treatment did increase the rate of thromboembolic events and gallbladder disease. Expand
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Treatment for 6.8 years with estrogen plus progestin in older women with coronary disease increased the rates of venous thromboembolism and biliary tract surgery and trends in other disease outcomes were not favorable and should be assessed in larger trials and in broader populations. Expand
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