Risks and benefits of early treatment of acute myocardial infarction with an angiotensin-converting enzyme inhibitor in patients with a history of arterial hypertension: analysis of the GISSI-3 database.

@article{Avanzini2002RisksAB,
  title={Risks and benefits of early treatment of acute myocardial infarction with an angiotensin-converting enzyme inhibitor in patients with a history of arterial hypertension: analysis of the GISSI-3 database.},
  author={Fausto Avanzini and Gabriele Ferrario and Luigi Santoro and Paolo Peci and Paolo Giani and Eugenio Santoro and Maria Grazia Franzosi and Gianni Tognoni},
  journal={American heart journal},
  year={2002},
  volume={144 6},
  pages={1018-25}
}
BACKGROUND Many trials have proved the benefits of early systematic treatment with angiotensin-converting enzyme inhibitors in patients with acute myocardial infarction (AMI). Pathophysiological studies, however, suggest potential harm in excessive reduction of blood pressure (BP) in hypertensive patients with ischemic heart disease. METHODS We analyzed data from the GISSI-3 (Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico) trial to assess the effects of early… CONTINUE READING

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