Risk to the Breast‐Fed Neonate From Codeine Treatment to the Mother: A Quantitative Mechanistic Modeling Study

  title={Risk to the Breast‐Fed Neonate From Codeine Treatment to the Mother: A Quantitative Mechanistic Modeling Study},
  author={S. Willmann and A. Edginton and K. Coboeken and G. Ahr and J. Lippert},
  journal={Clinical Pharmacology & Therapeutics},
  • S. Willmann, A. Edginton, +2 authors J. Lippert
  • Published 2009
  • Medicine
  • Clinical Pharmacology & Therapeutics
  • Administering codeine to breast‐feeding mothers had been considered safe until the recent death of a breast‐fed neonate whose mother had been prescribed codeine. We investigated the risk of opioid poisoning to breast‐fed neonates using coupled physiologically based pharmacokinetic models for the mother and child. Neonatal morphine plasma concentrations were simulated for various combinations of cytochrome P450 2D6 (CYP2D6) genotype and morphine clearance, assuming typical breast‐feeding… CONTINUE READING
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