Risk stratification and targeted neuroprotection in Parkinson disease utilising the glucocerebrosidase pathway

@inproceedings{Mullin2018RiskSA,
  title={Risk stratification and targeted neuroprotection in Parkinson disease utilising the glucocerebrosidase pathway},
  author={Stephen Mullin},
  year={2018}
}
OBJECTIVES: Glucocerebrosidase mutations represent genetically the most significant risk factor for Parkinson disease, however their penetrance is incomplete and variable such that only a minority of glucocerebrosidase mutation carriers will develop Parkinson disease. In this thesis I aimed to investigate the basis for this incomplete penetrance, to identify indices which may be used to predict Parkinson disease conversion amongst glucocerebrosidase mutation carriers and to test a putative… CONTINUE READING

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