Risk prediction for sporadic Alzheimer's disease using genetic risk score in the Han Chinese population

@inproceedings{Xiao2015RiskPF,
  title={Risk prediction for sporadic Alzheimer's disease using genetic risk score in the Han Chinese population},
  author={Qianyi Xiao and Zhi-jun Liu and Sha Tao and Yi-Min Sun and Deke Jiang and H. Li and Haitao Chen and Xu Liu and Brittany Lapin and Chi-Hsiung E Wang and S. Lilly Zheng and Jianfeng Xu and Zhi-ying Wu},
  booktitle={Oncotarget},
  year={2015}
}
More than 30 independent single-nucleotide polymorphisms (SNPs) have been associated with Alzheimer's disease (AD) risk by genome-wide association studies (GWAS) in European. We aimed to confirm these SNPs in Chinese Han and investigate the utility of these genetic markers. We randomly divided 459 sporadic AD (SAD) patients and 751 cognitively normal controls into two sets (discovery and testing). Thirty-three SAD risk-associated SNPs were firstly tested in the discovery set. Significant SNPs… CONTINUE READING

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Alzheimer's & dementia : the journal of the Alzheimer's Association • 2013
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