Risk of venous thrombosis with oral versus transdermal estrogen therapy among postmenopausal women

@article{Oli2010RiskOV,
  title={Risk of venous thrombosis with oral versus transdermal estrogen therapy among postmenopausal women},
  author={Val{\'e}rie Oli{\'e} and Marianne Canonico and Pierre-Yves Scarabin},
  journal={Current Opinion in Hematology},
  year={2010},
  volume={17},
  pages={457–463}
}
Purpose of reviewVenous thromboembolism (VTE) is a main harmful effect of oral estrogen therapy among postmenopausal women. Transdermal estrogens may be safer but early results need to be confirmed. This review provides a summary of the most recent findings regarding the VTE risk among oral versus transdermal estrogens users. Recent findingsSince 2008, we identified five relevant observational studies. Among them, two large cohort studies confirmed that oral but not transdermal estrogens were… 
Progestogens and venous thromboembolism in menopausal women: an updated oral versus transdermal estrogen meta-analysis
  • P. Scarabin
  • Medicine, Biology
    Climacteric : the journal of the International Menopause Society
  • 2018
TLDR
Clinical findings emphasize the safety advantage of transdermal estrogen combined with progesterone and support the current evidence-based recommendations on HT, especially in women at high VTE risk.
Oral vs Transdermal Estrogen Therapy and Vascular Events: A Systematic Review and Meta-Analysis.
TLDR
Observational evidence warranting low confidence suggests that compared to transdermal ET, oral ET may be associated with increased risk of VTE and DVT, but not MI.
Progestogens and venous thromboembolism among postmenopausal women using hormone therapy.
Postmenopausal hormone therapy and venous thromboembolism.
Hormone therapy and risk of venous thromboembolism among postmenopausal women
TLDR
Individual assessment of the benefit–risk ratio is needed before initiating treatment and oral estrogens should be avoided among women at high risk for venous thromboembolism, but norpregnane derivatives might be thrombogenic.
Oral versus transdermal estrogens and venous thromboembolism in postmenopausal women: what is new since 2003?
TLDR
A recent meta-analysis has confirmed the advantage of transdermal versus oral estrogens regarding VTE risk, despite divergences in rating the quality of evidence in this issue of Menopause.
Venous thromboembolism and cardiovascular disease complications in menopausal women using transdermal versus oral estrogen therapy
TLDR
This large matched-cohort study based on real-world data suggests that women receiving transdermal ET have significantly lower incidences of CVD events compared with those receiving oral ET, and that they also incur lower healthcare costs.
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TLDR
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TLDR
Oral estrogen therapy increases venous thromboembolism risk among postmenopausal women using hormone therapy and route of estrogen administration and concomitant progestogens type are 2 important determinants of thrombotic risk.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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