Risk of venous thromboembolism in carriers of factor V Leiden with a concomitant inherited thrombophilic defect: a retrospective analysis.

@article{Meinardi2001RiskOV,
  title={Risk of venous thromboembolism in carriers of factor V Leiden with a concomitant inherited thrombophilic defect: a retrospective analysis.},
  author={Johan R. Meinardi and Saskia Middeldorp and Pieter Jan de Kam and Maria M. W. Koopman and Elisabeth C M van Pampus and Karly Hamul{\'y}ak and Martin H. Prins and Harry Roger B{\"u}ller and Jan van der Meer},
  journal={Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis},
  year={2001},
  volume={12 8},
  pages={713-20}
}
Factor V Leiden is the most common genetic defect associated with venous thromboembolism. Its clinical expression is limited and shows a wide intrafamilial and interfamilial variation, which might be explained by the influence of other genetic risk factors. We retrospectively studied 226 patients with factor V Leiden and documented venous thromboembolism (probands) and 400 first-degree carrier relatives to assess the contribution of concomitant genetic risk factors to the occurrence of venous… CONTINUE READING

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