Risk of stroke associated with inhaled ipratropium bromide in chronic obstructive pulmonary disease: a population-based nested case-control study.

@article{Wang2012RiskOS,
  title={Risk of stroke associated with inhaled ipratropium bromide in chronic obstructive pulmonary disease: a population-based nested case-control study.},
  author={Meng-Ting Wang and Cheng-Liang Tsai and Y. W. Lo and Jun-Ting Liou and Wan-Ju Lee and I-Ching Lai},
  journal={International journal of cardiology},
  year={2012},
  volume={158 2},
  pages={
          279-84
        }
}
BACKGROUND Cardiovascular safety concerns about inhaled ipratropium bromide have recently been raised. Nonetheless, the specific stroke risk associated with ipratropium use has not been evaluated thoroughly. METHODS This was a population-based nested case-control study analyzing data from the National Health Insurance Research Database in Taiwan. A cohort of 15,396 newly-diagnosed chronic obstructive pulmonary disease (COPD) patients was included between 2001 and 2007, in which 1477 cases of… Expand
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References

SHOWING 1-10 OF 26 REFERENCES
Cardiovascular events associated with ipratropium bromide in COPD.
TLDR
A cohort study of 82,717 US veterans with a new diagnosis of COPD found an increased risk of CVEs associated with the use of ipratropium bromide within the past 6 months, consistent with previous concerns raised about the cardiovascular safety of ipRatropium Bromide. Expand
Inhaled anticholinergics and risk of major adverse cardiovascular events in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis.
TLDR
Inhaled anticholinergics are associated with a significantly increased risk of cardiovascular death, MI, or stroke among patients with COPD. Expand
Increased Risk of Stroke Associated With Nonsteroidal Anti-Inflammatory Drugs: A Nationwide Case–Crossover Study
TLDR
Use of selective and nonselective NSAIDs was associated with an increased risk of both ischemic and hemorrhagic stroke, strikingly high for parenteral ketorolac. Expand
Cardiovascular morbidity and the use of inhaled bronchodilators
TLDR
It is concluded that bronchodilator therapy for chronic obstructive diseases is associated with increased cardiovascular risk, especially in patients without previous cardiovascular diagnoses, and that this is unlikely due to the severity of the respiratory disease, since risk was not increased with ICS. Expand
Risk for Death Associated with Medications for Recently Diagnosed Chronic Obstructive Pulmonary Disease
TLDR
This large casecontrol study examined associations between medications and risk for death in veterans with newly diagnosed COPD and found Theophylline and ipratropium were associated with increased risk for respiratory and cardiovascular death, respectively. Expand
Why Are Patients With Chronic Obstructive Pulmonary Disease at Increased Risk of Cardiovascular Diseases?: The Potential Role of Systemic Inflammation in Chronic Obstructive Pulmonary Disease
TLDR
Low-grade systemic inflammation was present in participants with moderate to severe airflow obstruction and was associated with increased risk of cardiac injury, which may in part explain the high rates of cardiovascular complications in COPD. Expand
Effect of statin adherence on cerebrovascular disease in primary prevention.
TLDR
This study suggests a relatively low level of adherence to statin therapy needs to be improved, but more importantly, that adherence is associated with a risk reduction for cerebrovascular disease. Expand
Do Inhaled Anticholinergics Increase or Decrease the Risk of Major Cardiovascular Events?
TLDR
In conclusion, inhaled anticholinergics, especially tiotropium bromide, reduce COPD-related hospitalizations and deaths, and may improve total survival over time and it is possible that the reduction in respiratory morbidity could improve functional status and reduce adverse cardiac outcomes over time. Expand
Hospitalizations and mortality in the Lung Health Study.
TLDR
When all participants were considered and smoking status considered as a time-dependent covariate, smoking cessation was associated with significant reductions in fatal or nonfatal cardiovascular disease and coronary artery disease. Expand
Cardiovascular Safety of β2-Adrenoceptor Agonist Use in Patients with Obstructive Airway Disease
TLDR
Pooled data from randomised placebo-controlled trials indicate that β2-adrenoceptor agonist use increases the risk of adverse cardiovascular events by more than 2-fold compared with placebo, thus providing evidence that the association seen in case-control studies is a causal one. Expand
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