Risk of severe ovarian hyperstimulation syndrome in GnRH antagonist versus GnRH agonist protocol: RCT including 1050 first IVF/ICSI cycles.

@article{Toftager2016RiskOS,
  title={Risk of severe ovarian hyperstimulation syndrome in GnRH antagonist versus GnRH agonist protocol: RCT including 1050 first IVF/ICSI cycles.},
  author={Mette Toftager and Jeanette Bogstad and Thue Bryndorf and Kristine L{\o}ssl and J Rosk{\ae}r and Thomas S. Holland and Lisbeth Pr{\ae}torius and Anne Zedeler and Lisbeth Nilas and Anja Pinborg},
  journal={Human reproduction},
  year={2016},
  volume={31 6},
  pages={
          1253-64
        }
}
STUDY QUESTION Is the risk of severe ovarian hyperstimulation syndrome (OHSS) similar in a short GnRH antagonist and long GnRH agonist protocol in first cycle IVF/ICSI patients less than 40 years of age?. SUMMARY ANSWER There is an increased risk of severe OHSS in the long GnRH agonist group compared with the short GnRH antagonist protocol. WHAT IS KNOWN ALREADY?: In the most recent Cochrane review, the GnRH antagonist protocol was associated with a similar live birth rate (LBR), a similar on… CONTINUE READING
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