Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: a role for insulin resistance and diabetes.

@article{Fracanzani2008RiskOS,
  title={Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: a role for insulin resistance and diabetes.},
  author={Anna Ludovica Fracanzani and Luca Valenti and Elisabetta Bugianesi and Marco Andreoletti and Agostino Colli and Ester Vanni and Cristina Bertelli and Erika Fatta and Daniela Bignamini and Giulio Marchesini and Silvia Fargion},
  journal={Hepatology},
  year={2008},
  volume={48 3},
  pages={792-8}
}
UNLABELLED It is uncertain whether patients with nonalcoholic fatty liver disease (NAFLD) and normal alanine aminotransferase (ALT) have a milder disease and should undergo liver biopsy. We reviewed the histological data of 458 Italian patients with NAFLD in whom liver biopsy was indicated by altered liver enzymes (395 cases, 86%), or persistently elevated ferritin or long-lasting severe steatosis (63 cases). Factors associated with nonalcoholic steatohepatitis (NASH) and fibrosis >/= 2 were… CONTINUE READING
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