Risk of serious ventricular arrhythmia and sudden cardiac death in a cohort of users of domperidone: a nested case-control study.

@article{Johannes2010RiskOS,
  title={Risk of serious ventricular arrhythmia and sudden cardiac death in a cohort of users of domperidone: a nested case-control study.},
  author={Catherine B. Johannes and Cristina Varas-Lorenzo and Lisa J. McQuay and Kirk D. Midkiff and Daniel Fife},
  journal={Pharmacoepidemiology and drug safety},
  year={2010},
  volume={19 9},
  pages={881-8}
}
PURPOSE Limited information from spontaneous reports and results of two case-control studies raised concern about the cardiotoxicity of oral domperidone therapy. This case-control study nested in a retrospective cohort evaluated the combined risk of serious ventricular arrhythmia (SVA) and sudden cardiac death (SCD) in users of domperidone compared with users of proton pump inhibitors (PPIs), or non-users of these medications. METHODS A cohort of users of domperidone or a PPI from 1990 to… CONTINUE READING
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