Risk of oral infection with bovine spongiform encephalopathy agent in primates.


The uncertain extent of human exposure to bovine spongiform encephalopathy (BSE)--which can lead to variant Creutzfeldt-Jakob disease (vCJD)--is compounded by incomplete knowledge about the efficiency of oral infection and the magnitude of any bovine-to-human biological barrier to transmission. We therefore investigated oral transmission of BSE to non-human primates. We gave two macaques a 5 g oral dose of brain homogenate from a BSE-infected cow. One macaque developed vCJD-like neurological disease 60 months after exposure, whereas the other remained free of disease at 76 months. On the basis of these findings and data from other studies, we made a preliminary estimate of the food exposure risk for man, which provides additional assurance that existing public health measures can prevent transmission of BSE to man.

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@article{Lasmzas2005RiskOO, title={Risk of oral infection with bovine spongiform encephalopathy agent in primates.}, author={Corinne Ida Lasm{\'e}zas and Emmanuel E. Comoy and Steve A. C. Hawkins and Christian Herzog and Franck Mouthon and Timm Konold and Fr{\'e}d{\'e}ric Auvr{\'e} and Evelyne Correia and Nathalie Lescoutra-Etchegaray and Nicole Sal{\`e}s and Gerald A H Wells and P D Brown and Jean-Philippe Deslys}, journal={Lancet}, year={2005}, volume={365 9461}, pages={781-3} }