Risk of microsatellite-unstable colorectal cancer is associated jointly with smoking and nonsteroidal anti-inflammatory drug use.

@article{Chia2006RiskOM,
  title={Risk of microsatellite-unstable colorectal cancer is associated jointly with smoking and nonsteroidal anti-inflammatory drug use.},
  author={Victoria M. Chia and Polly A Newcomb and Jeannette Bigler and Libby M Morimoto and Stephen N. Thibodeau and John D. Potter},
  journal={Cancer research},
  year={2006},
  volume={66 13},
  pages={6877-83}
}
Smoking has been consistently associated with an increased risk of colorectal adenomas and hyperplastic polyps as well as colorectal cancer. Conversely, nonsteroidal anti-inflammatory drugs (NSAID) have been associated with reduced colorectal cancer risk. We conducted a population-based case-control study to evaluate the joint association between smoking and regular NSAID use with colorectal cancer risk; we also examined these associations stratified by tumor microsatellite instability (MSI… CONTINUE READING
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Smoking and NSAID use in relation to hyperplastic and adenomatous polyps of the colorectum

  • L Morimoto, PA Newcomb, M Mandelson
  • Cancer Epidemiol Biomarkers Prev 2003;12:1282s
  • 2003
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