Risk of hospitalization for upper gastrointestinal tract bleeding associated with ketorolac, other nonsteroidal anti-inflammatory drugs, calcium antagonists, and other antihypertensive drugs.

@article{Rodrguez1998RiskOH,
  title={Risk of hospitalization for upper gastrointestinal tract bleeding associated with ketorolac, other nonsteroidal anti-inflammatory drugs, calcium antagonists, and other antihypertensive drugs.},
  author={Luis Alberto Garc{\'i}a Rodr{\'i}guez and C. Cattaruzzi and Maria Grazia Troncon and L Agostinis},
  journal={Archives of internal medicine},
  year={1998},
  volume={158 1},
  pages={33-9}
}
BACKGROUND Nonsteroidal anti-inflammatory drugs (NSAIDs) cause substantial morbidity and mortality from upper gastrointestinal tract disease. Ketorolac tromethamine has been singled out as an NSAID with a distinct gastrotoxicity profile. Calcium channel blockers, a class of antihypertensive drugs, have also been found to increase the risk of gastrointestinal tract bleeding. METHODS We identified 1505 patients hospitalized because of upper gastrointestinal tract bleeding and/or perforation… CONTINUE READING

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