Risk of estrogen receptor-positive and -negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042.

  title={Risk of estrogen receptor-positive and -negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042.},
  author={Roger L Milne and Javier Ben{\'i}tez and Heli Nevanlinna and Tuomas Heikkinen and Kristiina Aittom{\"a}ki and Carl Blomqvist and Jos{\'e} Ignacio Arias and Mar{\'i}a Pilar Zamora and Barbara Burwinkel and Claus Rainer Bartram and Alfons Meindl and Rita Katharina Schmutzler and Angela Cox and Ian Wallace Brock and G. H. Elliott and Malcolm W. R. Reed and Melissa C. Southey and Letitia D Smith and Amanda B Spurdle and John L. Hopper and Fergus J. Couch and Janet E. Olson and Xianshu Wang and Zachary S. Fredericksen and Peter Schuermann and Michael Bremer and Peter Hillemanns and Thilo D{\"o}rk and Peter Devilee and Christie J. van Asperen and Rob A. E. M. Tollenaar and Caroline S Seynaeve and Per Hall and Kamila Czene and Jianping Liu and Yuqing Li and Shahana Ahmed and Alison M. Dunning and Melanie J Maranian and Paul P. D. Pharoah and Georgia Chenevix-Trench and Jonathan Beesley and Natalia Valerijevna Bogdanova and Natalia N. Antonenkova and Iosif Viktorovich Zalutsky and Hoda Anton-Culver and Argyrios Ziogas and Hiltrud Brauch and Christina Justenhoven and Y D Ko and Susanne Haas and Peter A. Fasching and Reiner Strick and Arif B. Ekici and Matthias W. Beckmann and Graham G. Giles and Gianluca Severi and Laura Baglietto and Dallas English and Olivia Fletcher and Nichola Johnson and Isabel Dos Santos Silva and Julian Peto and Clare Turnbull and Sarah Hines and Anthony Renwick and Nazneen Rahman and B\orge G. Nordestgaard and Stig Egil Bojesen and Henrik Flyger and Daehee Kang and Keun-young Yoo and Dong-Young Noh and Arto J Mannermaa and Vesa V. Kataja and Veli-Matti Kosma and Montserrat Garc{\'i}a-Closas and Stephen J. Chanock and Jolanta Lissowska and Louise A Brinton and Jenny Chang-Claude and Shan Wang-gohrke and Chen-yang Shen and H. Wang and Jyh-Cherng Yu and Sou-Tong Chen and Marina A Bermisheva and Tatjana Nikolaeva and Elza Khusnutdinova and Manjeet K. Humphreys and Jonathan Morrison and Radka Platte and Douglas F. Easton},
  journal={Journal of the National Cancer Institute},
  volume={101 14},
BACKGROUND A recent genome-wide association study identified single-nucleotide polymorphism (SNP) 2q35-rs13387042 as a marker of susceptibility to estrogen receptor (ER)-positive breast cancer. We attempted to confirm this association using the Breast Cancer Association Consortium. METHODS 2q35-rs13387042 SNP was genotyped for 31 510 women with invasive breast cancer, 1101 women with ductal carcinoma in situ, and 35 969 female control subjects from 25 studies. Odds ratios (ORs) were estimated… CONTINUE READING


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