Risk of dominant mutation in older fathers: evidence from osteogenesis imperfecta.

  title={Risk of dominant mutation in older fathers: evidence from osteogenesis imperfecta.},
  author={Andrew Carothers and Susan J McAllion and Colin R. Paterson},
  journal={Journal of medical genetics},
  volume={23 3},
The mean paternal age at birth of 80 presumed mutant cases of dominant osteogenesis imperfecta (OI) was significantly higher than that of population controls and remained so after adjusting for maternal age. There was also an increase in mean maternal age (not significant) which disappeared after adjusting for paternal age. No significant increase in maternal or paternal age was found in cases having OI either of a dominant type with an affected parent or of a type (Sillence type III) usually… CONTINUE READING

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