Risk of diabetic nephropathy in type 1 diabetes is associated with functional polymorphisms in RANTES receptor gene (CCR5): a sex-specific effect.

@article{Mlynarski2005RiskOD,
  title={Risk of diabetic nephropathy in type 1 diabetes is associated with functional polymorphisms in RANTES receptor gene (CCR5): a sex-specific effect.},
  author={Wojciech M Mlynarski and Grzegorz P Placha and Pawel P. Wolkow and Jacek P Bochenski and James H. Warram and Andrzej S Krolewski},
  journal={Diabetes},
  year={2005},
  volume={54 11},
  pages={3331-5}
}
Chemokines and their receptors have been implicated in the development of diabetic nephropathy. To determine whether the risk of diabetic nephropathy is influenced by two functional polymorphisms in the regulated upon activation normal T-cell expressed and secreted (RANTES) receptor gene (CCR5), we recruited patients with type 1 diabetes, including 496 case subjects with overt proteinuria or end-stage renal disease and 298 control subjects with normoalbuminuria. Male carriers of the 59029G… CONTINUE READING