Risk of dementia in parents of probands with and without the apolipoprotein E4 allele. The EVA study.

  title={Risk of dementia in parents of probands with and without the apolipoprotein E4 allele. The EVA study.},
  author={S Danet and Thierry Brousseau and Florence Richard and Philippe Amouyel and C Berr},
  journal={Journal of epidemiology and community health},
  volume={53 7},
STUDY OBJECTIVE Age, family history of dementia and the epsilon 4 allele of the apolipoprotein E gene have been associated with Alzheimer's disease (AD). Considering the strength of APOE-epsilon 4 as a genetic risk factor for AD, this factor might explain a large part of the association between AD and a family history of dementia. Therefore, in the general population, a higher frequency of dementia should be observed among parents of probands with at least one epsilon 4 allele than in parents… CONTINUE READING

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