Risk of colorectal cancer associated with the C677T polymorphism in 5,10-methylenetetrahydrofolate reductase in Portuguese patients depends on the intake of methyl-donor nutrients.

@article{Guerreiro2008RiskOC,
  title={Risk of colorectal cancer associated with the C677T polymorphism in 5,10-methylenetetrahydrofolate reductase in Portuguese patients depends on the intake of methyl-donor nutrients.},
  author={Catarina Sousa Guerreiro and Bruno Carmona and Susana A Gonçalves and Elisabete Carolino and Paulo O Fidalgo and Miguel S{\'a}nchez Brito and Carlos Nobre Leit{\~a}o and Marilia L. Cravo},
  journal={The American journal of clinical nutrition},
  year={2008},
  volume={88 5},
  pages={1413-8}
}
BACKGROUND Polymorphisms located in genes involved in the metabolism of folate and some methyl-related nutrients are implicated in colorectal cancer (CRC). OBJECTIVE We evaluated the association of 3 genetic polymorphisms [C677T MTHFR (methylene tetrahydrofolate reductase), A2756G MTR (methionine synthase), and C1420T SHMT (serine hydroxymethyltransferase)] with the intake of methyl-donor nutrients in CRC risk. DESIGN Patients with CRC (n = 196) and healthy controls (n = 200) matched for… CONTINUE READING