Risk of cardiovascular events associated with selective COX-2 inhibitors.

  title={Risk of cardiovascular events associated with selective COX-2 inhibitors.},
  author={D Mukherjee and Steven E. Nissen and Eric J. Topol},
  volume={286 8},
Atherosclerosis is a process with inflammatory features and selective cyclooxygenase 2 (COX-2) inhibitors may potentially have antiatherogenic effects by virtue of inhibiting inflammation. However, by decreasing vasodilatory and antiaggregatory prostacyclin production, COX-2 antagonists may lead to increased prothrombotic activity. To define the cardiovascular effects of COX-2 inhibitors when used for arthritis and musculoskeletal pain in patients without coronary artery disease, we performed a… 

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