Risk of cardiovascular events associated with selective COX-2 inhibitors.
@article{Mukherjee2001RiskOC, title={Risk of cardiovascular events associated with selective COX-2 inhibitors.}, author={D. Mukherjee and S. Nissen and E. Topol}, journal={JAMA}, year={2001}, volume={286 8}, pages={ 954-9 } }
Atherosclerosis is a process with inflammatory features and selective cyclooxygenase 2 (COX-2) inhibitors may potentially have antiatherogenic effects by virtue of inhibiting inflammation. However, by decreasing vasodilatory and antiaggregatory prostacyclin production, COX-2 antagonists may lead to increased prothrombotic activity. To define the cardiovascular effects of COX-2 inhibitors when used for arthritis and musculoskeletal pain in patients without coronary artery disease, we performed a… Expand
Paper Mentions
News Article
News Article
Interventional Clinical Trial
The study is going to compare two different doses of aspirin for the treatment of heart
disease in combination with the anticlotting medication ticagrelor. One of these doses of… Expand
Conditions | Acute Coronary Syndrome |
---|---|
Intervention | Drug |
News Article
1,190 Citations
Selective COX-2 Inhibition Improves Endothelial Function in Coronary Artery Disease
- Medicine
- Circulation
- 2003
- 271
Cardiovascular thrombotic events in arthritis trials of the cyclooxygenase-2 inhibitor celecoxib.
- Medicine
- The American journal of cardiology
- 2003
- 182
Cardiovascular hazard and non-steroidal anti-inflammatory drugs.
- Medicine
- Current opinion in pharmacology
- 2005
- 96
Cardiovascular hazard of selective COX-2 inhibitors: myth or reality?
- Medicine
- Expert opinion on drug safety
- 2002
- 13
Cardiovascular effects of the selective cyclooxygenase-2 inhibitors.
- Medicine
- Sub-cellular biochemistry
- 2007
- 11
- PDF
Cyclooxygenase-2 inhibitors: Is there an association with coronary or renal events?
- Medicine
- Current atherosclerosis reports
- 2003
- 21
Understanding the NSAID related risk of vascular events
- Medicine
- BMJ : British Medical Journal
- 2006
- 36
- PDF
References
SHOWING 1-10 OF 47 REFERENCES
Outcome of specific COX-2 inhibition in rheumatoid arthritis.
- Medicine
- The Journal of rheumatology. Supplement
- 1997
- 112
Gastrointestinal tolerability of the selective cyclooxygenase-2 (COX-2) inhibitor rofecoxib compared with nonselective COX-1 and COX-2 inhibitors in osteoarthritis.
- Medicine
- Archives of internal medicine
- 2000
- 162
- PDF
The Cyclooxygenase-2 Inhibitors: Safety and Effectiveness
- Medicine
- The Annals of pharmacotherapy
- 1999
- 93
Effects of specific inhibition of cyclooxygenase-2 on sodium balance, hemodynamics, and vasoactive eicosanoids.
- Chemistry, Medicine
- The Journal of pharmacology and experimental therapeutics
- 1999
- 613
- PDF
Reduced risk of upper gastrointestinal ulcer complications with celecoxib, a novel COX-2 inhibitor
- Medicine
- American Journal of Gastroenterology
- 2000
- 294
Cyclooxygenase-1 and -2-dependent prostacyclin formation in patients with atherosclerosis.
- Medicine
- Circulation
- 2000
- 368
- PDF
Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients.
- Medicine
- The New England journal of medicine
- 2000
- 7,291