Risk of cardiovascular events and rofecoxib: cumulative meta-analysis
@article{Jni2004RiskOC, title={Risk of cardiovascular events and rofecoxib: cumulative meta-analysis}, author={Peter J{\"u}ni and Linda Korkor Nartey and Stephan Reichenbach and Rebekka Sterchi and P. A. Dieppe and Matthias Egger}, journal={The Lancet}, year={2004}, volume={364}, pages={2021-2029} }
792 Citations
Risk of Cardiovascular Events and Celecoxib: a Systematic Review and Meta-Analysis
- Medicine
- 2006
The available data indicate an increased risk of myocardial infarction with celecoxib therapy, consistent with a class effect for COX-2 specific inhibitors.
Risk of cardiovascular events and celecoxib: a systematic review and meta-analysis.
- MedicineJournal of the Royal Society of Medicine
- 2006
The available data indicate an increased risk of myocardial infarction with celecoxib therapy, consistent with a class effect for COX-2 specific inhibitors.
Cardiovascular risk and inhibition of cyclooxygenase: a systematic review of the observational studies of selective and nonselective inhibitors of cyclooxygenase 2.
- MedicineJAMA
- 2006
It is suggested that celecoxib in commonly used doses may not increase the risk, contradicts claims of a protective effect of naproxen, and raises serious questions about the safety of diclofenac, an older drug.
Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial.
- MedicineThe New England journal of medicine
- 2005
Among patients with a history of colorectal adenomas, the use of rofecoxib was associated with an increased cardiovascular risk, and cardiovascular mortality was similar in the two groups.
A Comparison of Reported Gastrointestinal and Thromboembolic Events Between Rofecoxib and Celecoxib Using Observational Data
- MedicineDrug safety
- 2005
A retrospective comparison of PEM studies conducted for rofecoxib and celecoxib contributes to the understanding of the association between COX-2 inhibitors and thromboembolic events.
Non-steroidal anti-inflammatory drugs and myocardial infarctions: comparative systematic review of evidence from observational studies and randomised controlled trials
- MedicineAnnals of the rheumatic diseases
- 2007
The overall risk of myocardial infarction with NSAIDs and cyclo-oxygenase-2-specific drugs was small; rofecoxib showed the highest risk.
Nonsteroidal Antiinflammatory Drugs, Acetaminophen, and the Risk of Cardiovascular Events
- MedicineCirculation
- 2006
Use of NSAIDs or acetaminophen at high frequency or dose is associated with a significantly increased risk for major cardiovascular events, although more moderate use did not confer substantial risk.
Cardiovascular issues of COX-2 inhibitors and NSAIDs.
- MedicineAustralian family physician
- 2005
The available evidence using a PubMed search for increased CV risk with COX-2 inhibitors and NSAIDs is reviewed, possible mechanisms are explored, and recommendations for their appropriate use in clinical practice are made.
Long-term Risk of Ischemic Stroke Associated with Rofecoxib
- Medicine, PsychologyCardiovascular Drugs and Therapy
- 2007
Based on extended follow-up data, APPROVe is the first trial to report an increase in ischemic stroke risk with rofecoxib compared to placebo and should be further studied to determine whether patients previously exposed to rofECoxib remain at an increased risk.
COX 2 inhibitors, traditional NSAIDs, and the heart
- MedicineBMJ : British Medical Journal
- 2005
Rofecoxib had been marketed as the non-steroidal anti-inflammatory drug (NSAID) of choice because selective inhibition of the isoform 2 of the cyclooxygenase (COX 2) enzyme made it highly effective but free from gastrointestinal toxicity.
References
SHOWING 1-10 OF 47 REFERENCES
Nonsteroidal Antiinflammatory Drugs and the Risk of Myocardial Infarction in the General Population
- MedicineCirculation
- 2004
The results do not support the existence of a clinically meaningful interaction between aspirin and NSAIDs, including ibuprofen, including aspirin taken concomitantly.
Effect of selective cyclooxygenase 2 inhibitors and naproxen on short-term risk of acute myocardial infarction in the elderly.
- MedicineArchives of internal medicine
- 2003
The findings of this observational study suggest no increase in the short-term risk of AMI among users of selective cyclooxygenase 2 inhibitors as commonly used in clinical practice and do not support a short- term reduced risk ofAMI with naproxen.
Comparison of cardiovascular thrombotic events in patients with osteoarthritis treated with rofecoxib versus nonselective nonsteroidal anti-inflammatory drugs (ibuprofen, diclofenac, and nabumetone).
- MedicineThe American journal of cardiology
- 2002
COX-2 selective non-steroidal anti-inflammatory drugs and risk of serious coronary heart disease
- MedicineThe Lancet
- 2002
Relationship Between Selective Cyclooxygenase-2 Inhibitors and Acute Myocardial Infarction in Older Adults
- MedicineCirculation
- 2004
Current rofecoxib use was associated with an elevated relative risk of AMI compared with celecoxib use and no NSAID use, and Dosages of rofECoxib >25 mg were associated with a higher risk than dosages ≤25 mg, which was elevated in the first 90 days of use but not thereafter.
Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial.
- Medicine, PsychologyJAMA
- 2003
The results of this study indicate that rofecoxib or low-dose naproxen does not slow cognitive decline in patients with mild-to-moderate AD.
Non-steroidal anti-inflammatory drugs and risk of serious coronary heart disease: an observational cohort study
- MedicineThe Lancet
- 2002
Gastrointestinal Tolerability and Effectiveness of Rofecoxib versus Naproxen in the Treatment of Osteoarthritis
- MedicineAnnals of Internal Medicine
- 2003
A pooled analysis of 8 efficacy trials in osteoarthritis and a large prospective study of outcomes in rheumatoid arthritis showed that rofecoxib maintained efficacy and resulted in a significantly lower incidence of serious GI toxicity compared with nonspecific dual COX inhibitors.
Association between naproxen use and protection against acute myocardial infarction.
- MedicineArchives of internal medicine
- 2002
Compared with other NSAIDs, concurrent exposure to naproxen has a protective effect against acute myocardial infarction (AMI).
Comparison of the effect of rofecoxib (a cyclooxygenase 2 inhibitor), ibuprofen, and placebo on the gastroduodenal mucosa of patients with osteoarthritis: a randomized, double-blind, placebo-controlled trial. The Rofecoxib Osteoarthritis Endoscopy Multinational Study Group.
- MedicineArthritis and rheumatism
- 2000
At 2-4 times the therapeutically effective dose, rofecoxib caused fewer endoscopically detected ulcers than did ibuprofen.