Risk of Upper Gastrointestinal Bleeding and the Degree of Serotonin Reuptake Inhibition by Antidepressants

@article{Vidal2008RiskOU,
  title={Risk of Upper Gastrointestinal Bleeding and the Degree of Serotonin Reuptake Inhibition by Antidepressants},
  author={Xavier Vidal and Luisa Ib{\'a}{\~n}ez and Lourdes Vendrell and A Conforti and Joan-Ramon Laporte and The Spanish-Italian Collaborative Group for the Epidem Bleeding},
  journal={Drug Safety},
  year={2008},
  volume={31},
  pages={159-168}
}
AbstractBackground and objective: Selective serotonin reuptake inhibitor (SSRI) antidepressants can inhibit uptake of serotonin by platelets, and their use may predispose patients to bleeding. Case reports and observational studies from databases have suggested an association between the use of SSRIs and gastrointestinal bleeding. Their risk appears to be increased if they are concurrently used with aspirin (acetylsalicylic acid) or with other NSAIDs. With the aim of establishing the risk of… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 27 CITATIONS

A Review of Nonsteroidal Anti-inflammatory Drugs.

  • AANA journal
  • 2015
VIEW 3 EXCERPTS
CITES BACKGROUND